10,601 research outputs found
Profile Likelihood Biclustering
Biclustering, the process of simultaneously clustering the rows and columns
of a data matrix, is a popular and effective tool for finding structure in a
high-dimensional dataset. Many biclustering procedures appear to work well in
practice, but most do not have associated consistency guarantees. To address
this shortcoming, we propose a new biclustering procedure based on profile
likelihood. The procedure applies to a broad range of data modalities,
including binary, count, and continuous observations. We prove that the
procedure recovers the true row and column classes when the dimensions of the
data matrix tend to infinity, even if the functional form of the data
distribution is misspecified. The procedure requires computing a combinatorial
search, which can be expensive in practice. Rather than performing this search
directly, we propose a new heuristic optimization procedure based on the
Kernighan-Lin heuristic, which has nice computational properties and performs
well in simulations. We demonstrate our procedure with applications to
congressional voting records, and microarray analysis.Comment: 40 pages, 11 figures; R package in development at
https://github.com/patperry/biclustp
Minimax rank estimation for subspace tracking
Rank estimation is a classical model order selection problem that arises in a
variety of important statistical signal and array processing systems, yet is
addressed relatively infrequently in the extant literature. Here we present
sample covariance asymptotics stemming from random matrix theory, and bring
them to bear on the problem of optimal rank estimation in the context of the
standard array observation model with additive white Gaussian noise. The most
significant of these results demonstrates the existence of a phase transition
threshold, below which eigenvalues and associated eigenvectors of the sample
covariance fail to provide any information on population eigenvalues. We then
develop a decision-theoretic rank estimation framework that leads to a simple
ordered selection rule based on thresholding; in contrast to competing
approaches, however, it admits asymptotic minimax optimality and is free of
tuning parameters. We analyze the asymptotic performance of our rank selection
procedure and conclude with a brief simulation study demonstrating its
practical efficacy in the context of subspace tracking.Comment: 10 pages, 4 figures; final versio
Direct Evidence for the Source of Reported Magnetic Behavior in "CoTe"
In order to unambiguously identify the source of magnetism reported in recent
studies of the Co-Te system, two sets of high-quality, epitaxial CoTe films
(thickness 300 nm) were prepared by pulse laser deposition (PLD).
X-ray diffraction (XRD) shows that all of the films are epitaxial along the
[001] direction and have the hexagonal NiAs structure. There is no indication
of any second phase metallic Co peaks (either or ) in the XRD
patterns. The two sets of CoTe films were grown on various substrates with
PLD targets having Co:Te in the atomic ratio of 50:50 and 35:65. From the
measured lattice parameters for the former and
for the latter, the compositions CoTe (63.1% Te) and CoTe
(63.8% Te), respectively, are assigned to the principal phase. Although XRD
shows no trace of metallic Co second phase, the magnetic measurements do show a
ferromagnetic contribution for both sets of films with the saturation
magnetization values for the CoTe films being approximately four times
the values for the CoTe films. Co spin-echo nuclear magnetic
resonance (NMR) clearly shows the existence of metallic Co inclusions in the
films. The source of weak ferromagnetism reported in several recent studies is
due to the presence of metallic Co, since the stoichiometric composition "CoTe"
does not exist.Comment: 19 pages, 7 figure
Tumors in von Hippel–Lindau Syndrome: From Head to Toe—Comprehensive State-of-the-Art Review
Von Hippel–Lindau syndrome (VHL) is an autosomal-dominant hereditary tumor disease that arises owing to germline mutations in the VHL gene, located on the short arm of chromosome 3. Patients with VHL may develop multiple benign and malignant tumors involving various organ systems, including retinal hemangioblastomas (HBs), central nervous system (CNS) HBs, endolymphatic sac tumors, pancreatic neuroendocrine tumors, pancreatic cystadenomas, pancreatic cysts, clear cell renal cell carcinomas, renal cysts, pheochromocytomas, paragangliomas, and epididymal and broad ligament cystadenomas. The VHL/hypoxia-inducible factor pathway is believed to play a key role in the pathogenesis of VHL-related tumors. The diagnosis of VHL can be made clinically when the characteristic clinical history and findings have manifested, such as the presence of two or more CNS HBs. Genetic testing for heterozygous germline VHL mutation may also be used to confirm the diagnosis of VHL. Imaging plays an important role in the diagnosis and surveillance of patients with VHL. Familiarity with the clinical and imaging manifestations of the various VHL-related tumors is important for early detection and guiding appropriate management. The purpose of this article is to discuss the molecular cytogenetics and clinical manifestations of VHL, review the characteristic multimodality imaging features of the various VHL-related tumors affecting multiple organ systems, and discuss the latest advances in management of VHL, including current recommendations for surveillance and screening
Partition Functions, the Bekenstein Bound and Temperature Inversion in Anti-de Sitter Space and its Conformal Boundary
We reformulate the Bekenstein bound as the requirement of positivity of the
Helmholtz free energy at the minimum value of the function L=E- S/(2\pi R),
where R is some measure of the size of the system. The minimum of L occurs at
the temperature T=1/(2\pi R). In the case of n-dimensional anti-de Sitter
spacetime, the rather poorly defined size R acquires a precise definition in
terms of the AdS radius l, with R=l/(n-2). We previously found that the
Bekenstein bound holds for all known black holes in AdS. However, in this paper
we show that the Bekenstein bound is not generally valid for free quantum
fields in AdS, even if one includes the Casimir energy. Some other aspects of
thermodynamics in anti-de Sitter spacetime are briefly touched upon.Comment: Latex, 32 page
On two dimensional coupled bosons and fermions
We study complex bosons and fermions coupled through a generalized Yukawa
type coupling in the large-N_c limit following ideas of Rajeev [Int. Jour. Mod.
Phys. A 9 (1994) 5583]. We study a linear approximation to this model. We show
that in this approximation we do not have boson-antiboson and
fermion-antifermion bound states occuring together. There is a possibility of
having only fermion-antifermion bound states. We support this claim by finding
distributional solutions with energies lower than the two mass treshold in the
fermion sector. This also has implications from the point of view of scattering
theory to this model. We discuss some aspects of the scattering above the two
mass treshold of boson pairs and fermion pairs. We also briefly present a
gauged version of the same model and write down the linearized equations of
motion.Comment: 25 pages, no figure
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